Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats
المؤلفون المشاركون
Chen, Li
Wang, Xiaoting
Zhang, Jian
Dang, Chao
Liu, Gang
Liang, Zhijian
Huang, Gelun
Zhao, Weijia
Zeng, Jinsheng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Tongxinluo is a traditional Chinese medicine compound with the potential to promote the neuronal functional recovery in cerebral ischemic infarction.
Objective.
This study aimed to disclose whether tongxinluo promotes neurological functional recovery and neurogenesis and angiogenesis in the infarcted area and SVZ after cerebral ischemic infarction in hypertensive rats.
Methods.
The ischemic model was prepared by distal middle cerebral artery occlusion (MCAO) in hypertensive rats.
Tongxinluo was administrated 24 h after MCAO and lasted for 3, 7, or 14 days.
Behavioral tests were performed to evaluate the protection of tongxinluo.
Immunochemical staining was applied on brain tissue to evaluate the effects of tongxinluo on neurogenesis and vascularization in the MCAO model rats.
Results.
Postinjury administration of tongxinluo ameliorated the neuronal function deficit in the MCAO model rats.
As evidenced by the immunochemical staining, BrdU+/DCX+, BrdU+/nestin+, and BrdU+ vascular endothelial cells were promoted to proliferate in SVZ after tongxinluo administration.
The matured neurons stained by NeuN and vascularization by laminin staining were observed after tongxinluo administration in the peri-infarct area.
Conclusion.
Tongxinluo postischemia administration could ameliorate the neurological function deficit in the model rats.
Possible mechanisms are related to neurogenesis and angiogenesis in the peri-infarct area and SVZ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Li& Wang, Xiaoting& Zhang, Jian& Dang, Chao& Liu, Gang& Liang, Zhijian…[et al.]. 2016. Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104431
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Li…[et al.]. Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104431
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Li& Wang, Xiaoting& Zhang, Jian& Dang, Chao& Liu, Gang& Liang, Zhijian…[et al.]. Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104431
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104431
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر