Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats

Joint Authors

Chen, Li
Wang, Xiaoting
Zhang, Jian
Dang, Chao
Liu, Gang
Liang, Zhijian
Huang, Gelun
Zhao, Weijia
Zeng, Jinsheng

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-03-16

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Background.

Tongxinluo is a traditional Chinese medicine compound with the potential to promote the neuronal functional recovery in cerebral ischemic infarction.

Objective.

This study aimed to disclose whether tongxinluo promotes neurological functional recovery and neurogenesis and angiogenesis in the infarcted area and SVZ after cerebral ischemic infarction in hypertensive rats.

Methods.

The ischemic model was prepared by distal middle cerebral artery occlusion (MCAO) in hypertensive rats.

Tongxinluo was administrated 24 h after MCAO and lasted for 3, 7, or 14 days.

Behavioral tests were performed to evaluate the protection of tongxinluo.

Immunochemical staining was applied on brain tissue to evaluate the effects of tongxinluo on neurogenesis and vascularization in the MCAO model rats.

Results.

Postinjury administration of tongxinluo ameliorated the neuronal function deficit in the MCAO model rats.

As evidenced by the immunochemical staining, BrdU+/DCX+, BrdU+/nestin+, and BrdU+ vascular endothelial cells were promoted to proliferate in SVZ after tongxinluo administration.

The matured neurons stained by NeuN and vascularization by laminin staining were observed after tongxinluo administration in the peri-infarct area.

Conclusion.

Tongxinluo postischemia administration could ameliorate the neurological function deficit in the model rats.

Possible mechanisms are related to neurogenesis and angiogenesis in the peri-infarct area and SVZ.

American Psychological Association (APA)

Chen, Li& Wang, Xiaoting& Zhang, Jian& Dang, Chao& Liu, Gang& Liang, Zhijian…[et al.]. 2016. Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104431

Modern Language Association (MLA)

Chen, Li…[et al.]. Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104431

American Medical Association (AMA)

Chen, Li& Wang, Xiaoting& Zhang, Jian& Dang, Chao& Liu, Gang& Liang, Zhijian…[et al.]. Tongxinluo Enhances Neurogenesis and Angiogenesis in Peri-Infarct Area and Subventricular Zone and Promotes Functional Recovery after Focal Cerebral Ischemic Infarction in Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104431

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1104431