Cortex phellodendri Extract Relaxes Airway Smooth Muscle

المؤلفون المشاركون

Chen, Weiwei
Tan, Li
Shen, Jinhua
Yu, Meng-Fei
Yang, Guangzhong
Liu, Qing-Hua
Jiang, Qiu-Ju
Dan, Hong
Zhu, He
Peng, Yong-Bo
Zhao, Ping
Xue, Lu
Ma, Liqun
Si, Xiao-Tang
Wang, Zhuo
Dai, Jiapei
Qin, Gangjian
Zou, Chunbin

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-04-27

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Cortex phellodendri is used to reduce fever and remove dampness and toxin.

Berberine is an active ingredient of C.

phellodendri.

Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C.

phellodendri has similar relaxant action was unclear.

An n-butyl alcohol extract of C.

phellodendri (NBAECP, nonberberine component) was prepared, which completely inhibits high K+- and acetylcholine- (ACH-) induced precontraction of airway smooth muscle in tracheal rings and lung slices from control and asthmatic mice, respectively.

The contraction induced by high K+ was also blocked by nifedipine, a selective blocker of L-type Ca2+ channels.

The ACH-induced contraction was partially inhibited by nifedipine and pyrazole 3, an inhibitor of TRPC3 and STIM/Orai channels.

Taken together, our data demonstrate that NBAECP can relax ASM by inhibiting L-type Ca2+ channels and TRPC3 and/or STIM/Orai channels, suggesting that NBAECP could be developed to a new drug for relieving bronchospasm.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Jiang, Qiu-Ju& Chen, Weiwei& Dan, Hong& Tan, Li& Zhu, He& Yang, Guangzhong…[et al.]. 2016. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104446

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Jiang, Qiu-Ju…[et al.]. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104446

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Jiang, Qiu-Ju& Chen, Weiwei& Dan, Hong& Tan, Li& Zhu, He& Yang, Guangzhong…[et al.]. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104446

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1104446