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Cortex phellodendri Extract Relaxes Airway Smooth Muscle
Joint Authors
Chen, Weiwei
Tan, Li
Shen, Jinhua
Yu, Meng-Fei
Yang, Guangzhong
Liu, Qing-Hua
Jiang, Qiu-Ju
Dan, Hong
Zhu, He
Peng, Yong-Bo
Zhao, Ping
Xue, Lu
Ma, Liqun
Si, Xiao-Tang
Wang, Zhuo
Dai, Jiapei
Qin, Gangjian
Zou, Chunbin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cortex phellodendri is used to reduce fever and remove dampness and toxin.
Berberine is an active ingredient of C.
phellodendri.
Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C.
phellodendri has similar relaxant action was unclear.
An n-butyl alcohol extract of C.
phellodendri (NBAECP, nonberberine component) was prepared, which completely inhibits high K+- and acetylcholine- (ACH-) induced precontraction of airway smooth muscle in tracheal rings and lung slices from control and asthmatic mice, respectively.
The contraction induced by high K+ was also blocked by nifedipine, a selective blocker of L-type Ca2+ channels.
The ACH-induced contraction was partially inhibited by nifedipine and pyrazole 3, an inhibitor of TRPC3 and STIM/Orai channels.
Taken together, our data demonstrate that NBAECP can relax ASM by inhibiting L-type Ca2+ channels and TRPC3 and/or STIM/Orai channels, suggesting that NBAECP could be developed to a new drug for relieving bronchospasm.
American Psychological Association (APA)
Jiang, Qiu-Ju& Chen, Weiwei& Dan, Hong& Tan, Li& Zhu, He& Yang, Guangzhong…[et al.]. 2016. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104446
Modern Language Association (MLA)
Jiang, Qiu-Ju…[et al.]. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104446
American Medical Association (AMA)
Jiang, Qiu-Ju& Chen, Weiwei& Dan, Hong& Tan, Li& Zhu, He& Yang, Guangzhong…[et al.]. Cortex phellodendri Extract Relaxes Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104446