Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome
المؤلفون المشاركون
Yang, Ze-Min
Chen, Long-Hui
Hong, Min
Chen, Ying-Yu
Yang, Xiao-Rong
Tang, Si-Meng
Yuan, Qian-Fa
He, Zhen-Yu
Chen, Wei-Wen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To investigate serum microRNA (miRNA) profile and bioinformatics of patients with spleen-deficiency syndrome (SDS) and explore pathogenesis of SDS patients from miRNA levels, 10 patients with type 2 diabetes mellitus (T2DM), within which 5 patients were with SDS and the remaining were with blood stasis syndrome (BSS), and 5 healthy volunteers were recruited.
Serum miRNA profiles of SDS patients were identified by quantitative PCR array.
Target prediction and functional annotation for miRNAs were performed by miRSystem database.
The present study identified 11 candidate serum miRNAs for SDS patients, and their targets were significantly enriched in 18 KEGG pathways and 7 GO molecular functions.
Those enriched KEGG pathways included (1) metabolisms of carbohydrate, protein, amino acid, and fatty acid, (2) signaling pathways of insulin, ErbB, chemokine, calcium, and type II diabetes mellitus, (3) invasions of bacterium, Escherichia coli, and Shigella (Shigellosis), and (4) endocytosis and phagocytosis.
Those enriched GO molecular functions were mainly involved in transcription regulation and regulation of metabolism.
Our findings might elucidate the pathogenesis of SDS patients with disorders of substance metabolism and hypoimmunity from miRNA levels, as well as providing some miRNA biomarkers for clinical syndrome differentiation of SDS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Ze-Min& Chen, Long-Hui& Hong, Min& Chen, Ying-Yu& Yang, Xiao-Rong& Tang, Si-Meng…[et al.]. 2016. Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104448
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Ze-Min…[et al.]. Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104448
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Ze-Min& Chen, Long-Hui& Hong, Min& Chen, Ying-Yu& Yang, Xiao-Rong& Tang, Si-Meng…[et al.]. Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104448
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104448
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر