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Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome
Joint Authors
Yang, Ze-Min
Chen, Long-Hui
Hong, Min
Chen, Ying-Yu
Yang, Xiao-Rong
Tang, Si-Meng
Yuan, Qian-Fa
He, Zhen-Yu
Chen, Wei-Wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate serum microRNA (miRNA) profile and bioinformatics of patients with spleen-deficiency syndrome (SDS) and explore pathogenesis of SDS patients from miRNA levels, 10 patients with type 2 diabetes mellitus (T2DM), within which 5 patients were with SDS and the remaining were with blood stasis syndrome (BSS), and 5 healthy volunteers were recruited.
Serum miRNA profiles of SDS patients were identified by quantitative PCR array.
Target prediction and functional annotation for miRNAs were performed by miRSystem database.
The present study identified 11 candidate serum miRNAs for SDS patients, and their targets were significantly enriched in 18 KEGG pathways and 7 GO molecular functions.
Those enriched KEGG pathways included (1) metabolisms of carbohydrate, protein, amino acid, and fatty acid, (2) signaling pathways of insulin, ErbB, chemokine, calcium, and type II diabetes mellitus, (3) invasions of bacterium, Escherichia coli, and Shigella (Shigellosis), and (4) endocytosis and phagocytosis.
Those enriched GO molecular functions were mainly involved in transcription regulation and regulation of metabolism.
Our findings might elucidate the pathogenesis of SDS patients with disorders of substance metabolism and hypoimmunity from miRNA levels, as well as providing some miRNA biomarkers for clinical syndrome differentiation of SDS.
American Psychological Association (APA)
Yang, Ze-Min& Chen, Long-Hui& Hong, Min& Chen, Ying-Yu& Yang, Xiao-Rong& Tang, Si-Meng…[et al.]. 2016. Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104448
Modern Language Association (MLA)
Yang, Ze-Min…[et al.]. Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104448
American Medical Association (AMA)
Yang, Ze-Min& Chen, Long-Hui& Hong, Min& Chen, Ying-Yu& Yang, Xiao-Rong& Tang, Si-Meng…[et al.]. Serum MicroRNA Profiling and Bioinformatics of Patients with Spleen-Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104448
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104448