ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
المؤلفون المشاركون
Park, Ji-Ho
Kim, SangSeong
Kim, Hyun-Bum
Hwang, Eun-Sang
Choi, Ga-Young
Lee, Seok
Park, Tae-Suk
Lee, Cheol-Won
Lee, Eun-Suk
Kim, Young-Choong
Lee, Sung-Ok
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea.
Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive.
To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array.
Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102.
In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice.
Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine.
The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102.
In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors.
Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Hyun-Bum& Hwang, Eun-Sang& Choi, Ga-Young& Lee, Seok& Park, Tae-Suk& Lee, Cheol-Won…[et al.]. 2016. ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104451
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Hyun-Bum…[et al.]. ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104451
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Hyun-Bum& Hwang, Eun-Sang& Choi, Ga-Young& Lee, Seok& Park, Tae-Suk& Lee, Cheol-Won…[et al.]. ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104451
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104451
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر