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ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
Joint Authors
Park, Ji-Ho
Kim, SangSeong
Kim, Hyun-Bum
Hwang, Eun-Sang
Choi, Ga-Young
Lee, Seok
Park, Tae-Suk
Lee, Cheol-Won
Lee, Eun-Suk
Kim, Young-Choong
Lee, Sung-Ok
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea.
Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive.
To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array.
Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102.
In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice.
Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine.
The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102.
In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors.
Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects.
American Psychological Association (APA)
Kim, Hyun-Bum& Hwang, Eun-Sang& Choi, Ga-Young& Lee, Seok& Park, Tae-Suk& Lee, Cheol-Won…[et al.]. 2016. ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104451
Modern Language Association (MLA)
Kim, Hyun-Bum…[et al.]. ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104451
American Medical Association (AMA)
Kim, Hyun-Bum& Hwang, Eun-Sang& Choi, Ga-Young& Lee, Seok& Park, Tae-Suk& Lee, Cheol-Won…[et al.]. ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104451