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Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes
المؤلفون المشاركون
Aloui, Zohra
Messaoud, Chokri
Haoues, Meriam
Neffati, Noura
Bassoumi Jamoussi, Imen
Essafi-Benkhadir, Khadija
Boussaid, Mohamed
Guizani, Ikram
Karoui, Habib
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-11
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
We report the chemical composition and anti-Leishmania and antioxidant activity of Artemisia campestris L.
and Artemisia herba-alba Asso.
essential oils (EOs).
Our results showed that these extracts exhibit different antioxidant activities according to the used assay.
The radical scavenging effects determined by DPPH assay were of IC50 = 3.3 mg/mL and IC50 = 9.1 mg/mL for Artemisia campestris and Artemisia herba-alba essential oils, respectively.
However, antioxidant effects of both essential oils, determined by ferric-reducing antioxidant power (FRAP) assay, were in the same range (2.3 and 2.97 mg eq EDTA/g EO, resp.), while the Artemisia herba-alba essential oil showed highest chelating activity of Fe2+ ions (27.48 mM Fe2+).
Interestingly, we showed that both EOs possess dose-dependent activity against Leishmania infantum promastigotes with IC50 values of 68 μg/mL and 44 μg/mL for A.
herba-alba and A.
campestris, respectively.
We reported, for the first time, that antileishmanial activity of both EOs was mediated by cell apoptosis induction and cell cycle arrest at the sub-G0/G1 phase.
All our results showed that EOs from A.
herba-alba and A.
campestris plants are promising candidates as anti-Leishmania medicinal products.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aloui, Zohra& Messaoud, Chokri& Haoues, Meriam& Neffati, Noura& Bassoumi Jamoussi, Imen& Essafi-Benkhadir, Khadija…[et al.]. 2016. Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aloui, Zohra…[et al.]. Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aloui, Zohra& Messaoud, Chokri& Haoues, Meriam& Neffati, Noura& Bassoumi Jamoussi, Imen& Essafi-Benkhadir, Khadija…[et al.]. Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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