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Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes
Joint Authors
Aloui, Zohra
Messaoud, Chokri
Haoues, Meriam
Neffati, Noura
Bassoumi Jamoussi, Imen
Essafi-Benkhadir, Khadija
Boussaid, Mohamed
Guizani, Ikram
Karoui, Habib
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
We report the chemical composition and anti-Leishmania and antioxidant activity of Artemisia campestris L.
and Artemisia herba-alba Asso.
essential oils (EOs).
Our results showed that these extracts exhibit different antioxidant activities according to the used assay.
The radical scavenging effects determined by DPPH assay were of IC50 = 3.3 mg/mL and IC50 = 9.1 mg/mL for Artemisia campestris and Artemisia herba-alba essential oils, respectively.
However, antioxidant effects of both essential oils, determined by ferric-reducing antioxidant power (FRAP) assay, were in the same range (2.3 and 2.97 mg eq EDTA/g EO, resp.), while the Artemisia herba-alba essential oil showed highest chelating activity of Fe2+ ions (27.48 mM Fe2+).
Interestingly, we showed that both EOs possess dose-dependent activity against Leishmania infantum promastigotes with IC50 values of 68 μg/mL and 44 μg/mL for A.
herba-alba and A.
campestris, respectively.
We reported, for the first time, that antileishmanial activity of both EOs was mediated by cell apoptosis induction and cell cycle arrest at the sub-G0/G1 phase.
All our results showed that EOs from A.
herba-alba and A.
campestris plants are promising candidates as anti-Leishmania medicinal products.
American Psychological Association (APA)
Aloui, Zohra& Messaoud, Chokri& Haoues, Meriam& Neffati, Noura& Bassoumi Jamoussi, Imen& Essafi-Benkhadir, Khadija…[et al.]. 2016. Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104474
Modern Language Association (MLA)
Aloui, Zohra…[et al.]. Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104474
American Medical Association (AMA)
Aloui, Zohra& Messaoud, Chokri& Haoues, Meriam& Neffati, Noura& Bassoumi Jamoussi, Imen& Essafi-Benkhadir, Khadija…[et al.]. Asteraceae Artemisia campestris and Artemisia herba-alba Essential Oils Trigger Apoptosis and Cell Cycle Arrest in Leishmania infantum Promastigotes. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104474