Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology
المؤلفون المشاركون
Gao, Xiu-Mei
Ma, Xianghui
Lv, Bin
Li, Pan
Jiang, Xiaoqing
Zhou, Qian
Wang, Xiaoying
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Naoxintong capsule (NXT) is a commercial medicinal product approved by the China Food and Drug Administration which is used in the treatment of stroke and coronary heart disease.
However, the research on the composition and mechanism of NXT is still lacking.
Our research aimed to identify the absorbable components, potential targets, and associated pathways of NXT with network pharmacology method.
We explored the chemical compositions of NXT based on UPLC/Q-TOF-MS.
Then, we used the five principles of drug absorption to identify absorbable ingredients.
The databases of PharmMapper, Universal Protein, and the Molecule Annotation System were used to predict the main targets and related pathways.
By the five principles of drug absorption as a judgment rule, we identified 63 compositions that could be absorbed in the blood in all 81 chemical compositions.
Based on the constructed networks by the significant regulated 123 targets and 77 pathways, the main components that mediated the efficacy of NXT were organic acids, saponins, and tanshinones.
Radix Astragali was the critical herbal medicine in NXT, which contained more active components than other herbs and regulated more targets and pathways.
Our results showed that NXT had a therapeutic effect on heart diseases through the pattern “multiple components-multiple targets-multiple pathways.”
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Xianghui& Lv, Bin& Li, Pan& Jiang, Xiaoqing& Zhou, Qian& Wang, Xiaoying…[et al.]. 2016. Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Xianghui…[et al.]. Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Xianghui& Lv, Bin& Li, Pan& Jiang, Xiaoqing& Zhou, Qian& Wang, Xiaoying…[et al.]. Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر