Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology
Joint Authors
Gao, Xiu-Mei
Ma, Xianghui
Lv, Bin
Li, Pan
Jiang, Xiaoqing
Zhou, Qian
Wang, Xiaoying
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Naoxintong capsule (NXT) is a commercial medicinal product approved by the China Food and Drug Administration which is used in the treatment of stroke and coronary heart disease.
However, the research on the composition and mechanism of NXT is still lacking.
Our research aimed to identify the absorbable components, potential targets, and associated pathways of NXT with network pharmacology method.
We explored the chemical compositions of NXT based on UPLC/Q-TOF-MS.
Then, we used the five principles of drug absorption to identify absorbable ingredients.
The databases of PharmMapper, Universal Protein, and the Molecule Annotation System were used to predict the main targets and related pathways.
By the five principles of drug absorption as a judgment rule, we identified 63 compositions that could be absorbed in the blood in all 81 chemical compositions.
Based on the constructed networks by the significant regulated 123 targets and 77 pathways, the main components that mediated the efficacy of NXT were organic acids, saponins, and tanshinones.
Radix Astragali was the critical herbal medicine in NXT, which contained more active components than other herbs and regulated more targets and pathways.
Our results showed that NXT had a therapeutic effect on heart diseases through the pattern “multiple components-multiple targets-multiple pathways.”
American Psychological Association (APA)
Ma, Xianghui& Lv, Bin& Li, Pan& Jiang, Xiaoqing& Zhou, Qian& Wang, Xiaoying…[et al.]. 2016. Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104506
Modern Language Association (MLA)
Ma, Xianghui…[et al.]. Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104506
American Medical Association (AMA)
Ma, Xianghui& Lv, Bin& Li, Pan& Jiang, Xiaoqing& Zhou, Qian& Wang, Xiaoying…[et al.]. Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLCQ-TOF-MS and Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104506