Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
المؤلفون المشاركون
An, Xin
Liu, Guo-Chen
Yan, Jun-Ping
He, Qing
Pan, Zhi-Zhong
Ding, Pei-Rong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC).
We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014.
Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion.
RevMan software was used to analyze these data.
Nine trials were included in this meta-analysis, which covered a total of 3141 patients.
The meta-analysis showed that capecitabine group had statistically significant better pCR rates (OR, 1.34; 95% CI, 1.10–1.64; P = 0.0 03 ), T downstaging rates (OR, 1.58; 95% CI, 1.22–2.06; P = 0.0 007 ), N downstaging rates (OR, 2.06; 95% CI, 1.34–3.16; P = 0.0 01 ), less distant metastasis (OR, 0.63; 95% CI, 0.44–0.88; P = 0 .
007 ), and lowered leucocytes (OR, 0.25; 95% CI, 0.11–0.54; P = 0.0 005 ), but with higher incidence of hand-foot syndrome (HFS) (OR, 4.43; 95% CI, 1.59–12.33; P = 0.0 04 ).
Capecitabine was more efficient than 5-FU in terms of tumor response in neoadjuvant treatment for patients with LARC and favourably low toxicity with the exception of HFS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Guo-Chen& Yan, Jun-Ping& He, Qing& An, Xin& Pan, Zhi-Zhong& Ding, Pei-Rong. 2016. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104599
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Guo-Chen…[et al.]. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1104599
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Guo-Chen& Yan, Jun-Ping& He, Qing& An, Xin& Pan, Zhi-Zhong& Ding, Pei-Rong. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104599
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104599
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر