Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
Joint Authors
An, Xin
Liu, Guo-Chen
Yan, Jun-Ping
He, Qing
Pan, Zhi-Zhong
Ding, Pei-Rong
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC).
We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014.
Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion.
RevMan software was used to analyze these data.
Nine trials were included in this meta-analysis, which covered a total of 3141 patients.
The meta-analysis showed that capecitabine group had statistically significant better pCR rates (OR, 1.34; 95% CI, 1.10–1.64; P = 0.0 03 ), T downstaging rates (OR, 1.58; 95% CI, 1.22–2.06; P = 0.0 007 ), N downstaging rates (OR, 2.06; 95% CI, 1.34–3.16; P = 0.0 01 ), less distant metastasis (OR, 0.63; 95% CI, 0.44–0.88; P = 0 .
007 ), and lowered leucocytes (OR, 0.25; 95% CI, 0.11–0.54; P = 0.0 005 ), but with higher incidence of hand-foot syndrome (HFS) (OR, 4.43; 95% CI, 1.59–12.33; P = 0.0 04 ).
Capecitabine was more efficient than 5-FU in terms of tumor response in neoadjuvant treatment for patients with LARC and favourably low toxicity with the exception of HFS.
American Psychological Association (APA)
Liu, Guo-Chen& Yan, Jun-Ping& He, Qing& An, Xin& Pan, Zhi-Zhong& Ding, Pei-Rong. 2016. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104599
Modern Language Association (MLA)
Liu, Guo-Chen…[et al.]. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1104599
American Medical Association (AMA)
Liu, Guo-Chen& Yan, Jun-Ping& He, Qing& An, Xin& Pan, Zhi-Zhong& Ding, Pei-Rong. Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104599