Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study
المؤلفون المشاركون
Roytrakul, Sittiruk
Jittorntam, Paisan
Petraksa, Supanna
Sobhonslidsuk, Abhasnee
Wanichanuwat, Jirachaya
Numthavaj, Pawin
Sophonsritsuk, Areepan
Pugasub, Alongkorn
Kongsomgan, Anucha
Phakdeekitcharoen, Bunyong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients.
We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD.
Methods.
A cross-sectional study was performed in CHB patients taking nucleotide analogues.
Inclusion criteria were patients who were on adefovir or tenofovir as mono- or add-on therapy with lamivudine (LAM) >1 year.
Serum and urine were collected.
Fractional excretion of phosphate (FEPO4), uric acid (FEUA), and potassium was calculated.
Renal losses were defined based on the criteria: protein (24-hour urine protein >150 mg), glucose (glycosuria with normoglycemia), phosphate (FEPO4 >18%), uric acid (FEUA >15%), potassium (renal potassium losses with hypokalemia), and bicarbonate (normal gap acidosis).
Subclinical and overt proximal RTD were defined when 2 and ≥3 criteria presented.
Results.
Ninety-two patients were enrolled.
The mean duration of nucleotide analogue taking was 55.1±29.6 months.
Proximal RTD was found in 24 (26.1%) patients (subclinical 15 (16.3%) and overt 9 (9.8%)).
The severity of RTD was associated with the duration of nucleotide analogue (P=0.01).
Conclusions.
The prevalence of proximal RTD in CHB patients taking nucleotide analogues was 26%.
The severity of RTD was associated with the treatment duration.
Comprehensive testing is necessary for early detecting nucleotide analogue-related nephrotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sobhonslidsuk, Abhasnee& Wanichanuwat, Jirachaya& Numthavaj, Pawin& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. 2016. Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104639
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sobhonslidsuk, Abhasnee…[et al.]. Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1104639
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sobhonslidsuk, Abhasnee& Wanichanuwat, Jirachaya& Numthavaj, Pawin& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104639
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104639
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر