Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study
Joint Authors
Roytrakul, Sittiruk
Jittorntam, Paisan
Petraksa, Supanna
Sobhonslidsuk, Abhasnee
Wanichanuwat, Jirachaya
Numthavaj, Pawin
Sophonsritsuk, Areepan
Pugasub, Alongkorn
Kongsomgan, Anucha
Phakdeekitcharoen, Bunyong
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients.
We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD.
Methods.
A cross-sectional study was performed in CHB patients taking nucleotide analogues.
Inclusion criteria were patients who were on adefovir or tenofovir as mono- or add-on therapy with lamivudine (LAM) >1 year.
Serum and urine were collected.
Fractional excretion of phosphate (FEPO4), uric acid (FEUA), and potassium was calculated.
Renal losses were defined based on the criteria: protein (24-hour urine protein >150 mg), glucose (glycosuria with normoglycemia), phosphate (FEPO4 >18%), uric acid (FEUA >15%), potassium (renal potassium losses with hypokalemia), and bicarbonate (normal gap acidosis).
Subclinical and overt proximal RTD were defined when 2 and ≥3 criteria presented.
Results.
Ninety-two patients were enrolled.
The mean duration of nucleotide analogue taking was 55.1±29.6 months.
Proximal RTD was found in 24 (26.1%) patients (subclinical 15 (16.3%) and overt 9 (9.8%)).
The severity of RTD was associated with the duration of nucleotide analogue (P=0.01).
Conclusions.
The prevalence of proximal RTD in CHB patients taking nucleotide analogues was 26%.
The severity of RTD was associated with the treatment duration.
Comprehensive testing is necessary for early detecting nucleotide analogue-related nephrotoxicity.
American Psychological Association (APA)
Sobhonslidsuk, Abhasnee& Wanichanuwat, Jirachaya& Numthavaj, Pawin& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. 2016. Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104639
Modern Language Association (MLA)
Sobhonslidsuk, Abhasnee…[et al.]. Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1104639
American Medical Association (AMA)
Sobhonslidsuk, Abhasnee& Wanichanuwat, Jirachaya& Numthavaj, Pawin& Sophonsritsuk, Areepan& Petraksa, Supanna& Pugasub, Alongkorn…[et al.]. Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104639