Identification of the Key Genes and Pathways in Esophageal Carcinoma
المؤلفون المشاركون
Su, Peng
Wen, Shiwang
Zhang, Yuefeng
Li, Yong
Xu, Yanzhao
Zhu, Yonggang
Lv, Huilai
Zhang, Fan
Wang, Mingbo
Tian, Ziqiang
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
Esophageal carcinoma (EC) is a frequently common malignancy of gastrointestinal cancer in the world.
This study aims to screen key genes and pathways in EC and elucidate the mechanism of it.
Methods.
5 microarray datasets of EC were downloaded from Gene Expression Omnibus.
Differentially expressed genes (DEGs) were screened by bioinformatics analysis.
Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein-protein interaction (PPI) network construction were performed to obtain the biological roles of DEGs in EC.
Quantitative real-time polymerase chain reaction (qRT-PCR) was used to verify the expression level of DEGs in EC.
Results.
A total of 1955 genes were filtered as DEGs in EC.
The upregulated genes were significantly enriched in cell cycle and the downregulated genes significantly enriched in Endocytosis.
PPI network displayed CDK4 and CCT3 were hub proteins in the network.
The expression level of 8 dysregulated DEGs including CDK4, CCT3, THSD4, SIM2, MYBL2, CENPF, CDCA3, and CDKN3 was validated in EC compared to adjacent nontumor tissues and the results were matched with the microarray analysis.
Conclusion.
The significantly DEGs including CDK4, CCT3, THSD4, and SIM2 may play key roles in tumorigenesis and development of EC involved in cell cycle and Endocytosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Peng& Wen, Shiwang& Zhang, Yuefeng& Li, Yong& Xu, Yanzhao& Zhu, Yonggang…[et al.]. 2016. Identification of the Key Genes and Pathways in Esophageal Carcinoma. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104641
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Peng…[et al.]. Identification of the Key Genes and Pathways in Esophageal Carcinoma. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1104641
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Peng& Wen, Shiwang& Zhang, Yuefeng& Li, Yong& Xu, Yanzhao& Zhu, Yonggang…[et al.]. Identification of the Key Genes and Pathways in Esophageal Carcinoma. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104641
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104641
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر