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A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis
المؤلفون المشاركون
Shiga, Hisashi
Kuhroha, Masatake
Onodera, Motoyuki
Kimura, Tomoya
Hiramoto, Keiichiro
Endo, Katsuya
Kakuta, Yoichi
Shimosegawa, Tooru
Kinouchi, Yoshitaka
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background/Aims.
Antitumor necrosis factor antibodies and calcineurin inhibitors have shown good therapeutic efficacy for steroid-refractory ulcerative colitis (UC).
Although some studies have compared the efficacy of infliximab (IFX) and cyclosporin A, there are no published studies comparing IFX and tacrolimus (Tac).
This study aimed to compare therapeutic efficacies between IFX- and Tac-based strategies for steroid-refractory UC.
Methods.
Between July 2009 and August 2013, 95 patients with steroid-refractory UC received either IFX ( n = 48 ) or Tac ( n = 47 ) in our hospital.
In the IFX group, the patients continued to receive maintenance treatment with IFX.
In the Tac group, patients discontinued Tac treatment up to 3 months and subsequently received thiopurine.
We retrospectively compared the therapeutic outcomes between the groups.
Results.
There was no significant difference in the colectomy-free rate, clinical remission rate, and clinical response rate at 2 months between the groups.
However, relapse-free survival was significantly higher in the IFX group than in the Tac group ( p < 0.001 ; log-rank test).
The proportions of serious adverse events did not differ between the groups.
Conclusion.
The findings of our study showed that IFX and Tac have similar short-term therapeutic efficacy for steroid-refractory UC.
Maintenance treatment with IFX, however, yields better long-term outcomes than Tac-thiopurine bridging treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Endo, Katsuya& Onodera, Motoyuki& Shiga, Hisashi& Kuhroha, Masatake& Kimura, Tomoya& Hiramoto, Keiichiro…[et al.]. 2016. A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104650
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Endo, Katsuya…[et al.]. A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1104650
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Endo, Katsuya& Onodera, Motoyuki& Shiga, Hisashi& Kuhroha, Masatake& Kimura, Tomoya& Hiramoto, Keiichiro…[et al.]. A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104650
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104650
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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