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A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis
Joint Authors
Shiga, Hisashi
Kuhroha, Masatake
Onodera, Motoyuki
Kimura, Tomoya
Hiramoto, Keiichiro
Endo, Katsuya
Kakuta, Yoichi
Shimosegawa, Tooru
Kinouchi, Yoshitaka
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background/Aims.
Antitumor necrosis factor antibodies and calcineurin inhibitors have shown good therapeutic efficacy for steroid-refractory ulcerative colitis (UC).
Although some studies have compared the efficacy of infliximab (IFX) and cyclosporin A, there are no published studies comparing IFX and tacrolimus (Tac).
This study aimed to compare therapeutic efficacies between IFX- and Tac-based strategies for steroid-refractory UC.
Methods.
Between July 2009 and August 2013, 95 patients with steroid-refractory UC received either IFX ( n = 48 ) or Tac ( n = 47 ) in our hospital.
In the IFX group, the patients continued to receive maintenance treatment with IFX.
In the Tac group, patients discontinued Tac treatment up to 3 months and subsequently received thiopurine.
We retrospectively compared the therapeutic outcomes between the groups.
Results.
There was no significant difference in the colectomy-free rate, clinical remission rate, and clinical response rate at 2 months between the groups.
However, relapse-free survival was significantly higher in the IFX group than in the Tac group ( p < 0.001 ; log-rank test).
The proportions of serious adverse events did not differ between the groups.
Conclusion.
The findings of our study showed that IFX and Tac have similar short-term therapeutic efficacy for steroid-refractory UC.
Maintenance treatment with IFX, however, yields better long-term outcomes than Tac-thiopurine bridging treatment.
American Psychological Association (APA)
Endo, Katsuya& Onodera, Motoyuki& Shiga, Hisashi& Kuhroha, Masatake& Kimura, Tomoya& Hiramoto, Keiichiro…[et al.]. 2016. A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104650
Modern Language Association (MLA)
Endo, Katsuya…[et al.]. A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1104650
American Medical Association (AMA)
Endo, Katsuya& Onodera, Motoyuki& Shiga, Hisashi& Kuhroha, Masatake& Kimura, Tomoya& Hiramoto, Keiichiro…[et al.]. A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104650