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Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages
المؤلفون المشاركون
Ma, Weijie
Liu, Zhisu
Guo, Tao
He, Yukun
Liu, Quanyan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aims.
To understand the feasibility and efficacy of treatment with SAMe in patients with hepatitis B-related HCC with different Barcelona Clinic Liver Cancer (BCLC) stages.
Methods.
We retrospectively enrolled 697 patients with BCLC early-stage (stages 0-A) and advanced-stage (stages B-C) HCC who underwent SAMe therapy (354 cases) or no SAMe therapy (343 cases).
The baseline characteristics, postoperative recoveries, and 24-month overall survival rates of the patients in the 2 groups were compared.
Cox regression model analysis was performed to confirm the independent variables influencing the survival rate.
Results.
For patients in the early-stage (BCLC stages A1–A4) group, little benefit of SAMe therapy was observed.
For advanced-stage (BCLC B-C) patients, SAMe therapy reduced alanine aminotransferase (ALT) and aspartate transaminase (AST) levels and effectively delayed the recurrence time and enhanced the 24-month survival rate.
Cox regression model analysis in the advanced-stage group revealed that treatment with SAMe, preoperative viral load, and Child-Pugh grade were independent variables influencing survival time.
Conclusion.
SAMe therapy exhibited protective and therapeutic efficacy for BCLC advanced-stage HBV-related HCC patients.
And the efficacy of SAMe therapy should be further explored in randomized prospective clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Tao& He, Yukun& Ma, Weijie& Liu, Zhisu& Liu, Quanyan. 2016. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Tao…[et al.]. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Tao& He, Yukun& Ma, Weijie& Liu, Zhisu& Liu, Quanyan. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104679
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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