Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages
المؤلفون المشاركون
Ma, Weijie
Liu, Zhisu
Guo, Tao
He, Yukun
Liu, Quanyan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aims.
To understand the feasibility and efficacy of treatment with SAMe in patients with hepatitis B-related HCC with different Barcelona Clinic Liver Cancer (BCLC) stages.
Methods.
We retrospectively enrolled 697 patients with BCLC early-stage (stages 0-A) and advanced-stage (stages B-C) HCC who underwent SAMe therapy (354 cases) or no SAMe therapy (343 cases).
The baseline characteristics, postoperative recoveries, and 24-month overall survival rates of the patients in the 2 groups were compared.
Cox regression model analysis was performed to confirm the independent variables influencing the survival rate.
Results.
For patients in the early-stage (BCLC stages A1–A4) group, little benefit of SAMe therapy was observed.
For advanced-stage (BCLC B-C) patients, SAMe therapy reduced alanine aminotransferase (ALT) and aspartate transaminase (AST) levels and effectively delayed the recurrence time and enhanced the 24-month survival rate.
Cox regression model analysis in the advanced-stage group revealed that treatment with SAMe, preoperative viral load, and Child-Pugh grade were independent variables influencing survival time.
Conclusion.
SAMe therapy exhibited protective and therapeutic efficacy for BCLC advanced-stage HBV-related HCC patients.
And the efficacy of SAMe therapy should be further explored in randomized prospective clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Tao& He, Yukun& Ma, Weijie& Liu, Zhisu& Liu, Quanyan. 2016. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Tao…[et al.]. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Tao& He, Yukun& Ma, Weijie& Liu, Zhisu& Liu, Quanyan. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104679
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر