Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages
Joint Authors
Ma, Weijie
Liu, Zhisu
Guo, Tao
He, Yukun
Liu, Quanyan
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
To understand the feasibility and efficacy of treatment with SAMe in patients with hepatitis B-related HCC with different Barcelona Clinic Liver Cancer (BCLC) stages.
Methods.
We retrospectively enrolled 697 patients with BCLC early-stage (stages 0-A) and advanced-stage (stages B-C) HCC who underwent SAMe therapy (354 cases) or no SAMe therapy (343 cases).
The baseline characteristics, postoperative recoveries, and 24-month overall survival rates of the patients in the 2 groups were compared.
Cox regression model analysis was performed to confirm the independent variables influencing the survival rate.
Results.
For patients in the early-stage (BCLC stages A1–A4) group, little benefit of SAMe therapy was observed.
For advanced-stage (BCLC B-C) patients, SAMe therapy reduced alanine aminotransferase (ALT) and aspartate transaminase (AST) levels and effectively delayed the recurrence time and enhanced the 24-month survival rate.
Cox regression model analysis in the advanced-stage group revealed that treatment with SAMe, preoperative viral load, and Child-Pugh grade were independent variables influencing survival time.
Conclusion.
SAMe therapy exhibited protective and therapeutic efficacy for BCLC advanced-stage HBV-related HCC patients.
And the efficacy of SAMe therapy should be further explored in randomized prospective clinical trials.
American Psychological Association (APA)
Guo, Tao& He, Yukun& Ma, Weijie& Liu, Zhisu& Liu, Quanyan. 2016. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
Modern Language Association (MLA)
Guo, Tao…[et al.]. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
American Medical Association (AMA)
Guo, Tao& He, Yukun& Ma, Weijie& Liu, Zhisu& Liu, Quanyan. Feasibility and Efficacy of S-Adenosyl-L-methionine in Patients with HBV-Related HCC with Different BCLC Stages. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104679