Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication of Helicobacter pylori: A Comparative Study in a Cohort of Romanian Patients

الملخص EN

Objective.

This study compared the eradication rates of of Helicobacter pylori (HP) infection by a 7-day and 14-day anti-HP regimen.

Materials and Methods.

An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen A) of a proton pump inhibitor in association with clarithromycin and amoxicillin compared to a 14-day course (Regimen B).

Gastric biopsies were performed at baseline and two months after anti-HP treatment.

Results.

Seventy-eight patients aged 18–64 years (28 males, 50 females) diagnosed with HP infection were included.

Fifty-two (66.7%) patients received Regimen B and 26 (33.3%) Regimen A.

The overall eradication rate was 70.5%.

Better treatment response (p<0.01) was seen in Regimen B (44/52, 84.2% versus 11/26, 42.3%).

Significant improvement in histological features was seen in regimen B.

There has been significant overall reduction in endoscopic aspects of gastric and duodenal lesions in both regimens.

Younger patients ≤35 years had a better response to Regimen B.

Better treatment response was seen in women, urban residents, and those with tertiary level of education in both groups.

Conclusion.

14-day anti-HP regimen offered a significant better overall eradication of HP in study population.