Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication of Helicobacter pylori: A Comparative Study in a Cohort of Romanian Patients
Joint Authors
Arama, Victoria
Garg, Amit
Arama, Stefan Sorin
Tiliscan, Catalin
Negoita, Cristina
Croitoru, Alexandru
Mihai, Carmen Marina
Pop, Florinel
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
This study compared the eradication rates of of Helicobacter pylori (HP) infection by a 7-day and 14-day anti-HP regimen.
Materials and Methods.
An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen A) of a proton pump inhibitor in association with clarithromycin and amoxicillin compared to a 14-day course (Regimen B).
Gastric biopsies were performed at baseline and two months after anti-HP treatment.
Results.
Seventy-eight patients aged 18–64 years (28 males, 50 females) diagnosed with HP infection were included.
Fifty-two (66.7%) patients received Regimen B and 26 (33.3%) Regimen A.
The overall eradication rate was 70.5%.
Better treatment response (p<0.01) was seen in Regimen B (44/52, 84.2% versus 11/26, 42.3%).
Significant improvement in histological features was seen in regimen B.
There has been significant overall reduction in endoscopic aspects of gastric and duodenal lesions in both regimens.
Younger patients ≤35 years had a better response to Regimen B.
Better treatment response was seen in women, urban residents, and those with tertiary level of education in both groups.
Conclusion.
14-day anti-HP regimen offered a significant better overall eradication of HP in study population.
American Psychological Association (APA)
Arama, Stefan Sorin& Tiliscan, Catalin& Negoita, Cristina& Croitoru, Alexandru& Arama, Victoria& Mihai, Carmen Marina…[et al.]. 2015. Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication of Helicobacter pylori: A Comparative Study in a Cohort of Romanian Patients. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104702
Modern Language Association (MLA)
Arama, Stefan Sorin…[et al.]. Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication of Helicobacter pylori: A Comparative Study in a Cohort of Romanian Patients. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1104702
American Medical Association (AMA)
Arama, Stefan Sorin& Tiliscan, Catalin& Negoita, Cristina& Croitoru, Alexandru& Arama, Victoria& Mihai, Carmen Marina…[et al.]. Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication of Helicobacter pylori: A Comparative Study in a Cohort of Romanian Patients. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104702