Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease
المؤلفون المشاركون
Hawamdeh, Hasan
Al-Zoubi, Basim
Al Sharqi, Yasameen
Qasrawi, Ayman
Abdelaziz, Yousef
Barbar, Maha
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-27
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy.
Celiac specific antibodies are used as an initial screening test.
The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease.
Method.
The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed.
Result.
Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease.
There was statistically significant positive association between high anti-tTG titer and Marsh grading as 82% of patients with Marsh III had high anti-tTG titer (Chi2 18.5; P value 0.00; Odds Ratio 8.5).
The fraction of patients with Marsh III who were correctly identified as positive by anti-tTG titer ≥ 180 U/mL was high (sensitivity = 81.6).
Moreover, the fraction of patients with anti-tTG titer ≥ 180 U/mL who had Marsh III was also high (positive predictive value = 78.4).
Conclusion.
Anti-tTG titer ≥ 180 U/mL had significant positive association with Marsh III histopathological changes of celiac disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hawamdeh, Hasan& Al-Zoubi, Basim& Al Sharqi, Yasameen& Qasrawi, Ayman& Abdelaziz, Yousef& Barbar, Maha. 2016. Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hawamdeh, Hasan…[et al.]. Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hawamdeh, Hasan& Al-Zoubi, Basim& Al Sharqi, Yasameen& Qasrawi, Ayman& Abdelaziz, Yousef& Barbar, Maha. Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر