Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease

Joint Authors

Hawamdeh, Hasan
Al-Zoubi, Basim
Al Sharqi, Yasameen
Qasrawi, Ayman
Abdelaziz, Yousef
Barbar, Maha

Source

Gastroenterology Research and Practice

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-10-27

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases

Abstract EN

Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy.

Celiac specific antibodies are used as an initial screening test.

The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease.

Method.

The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed.

Result.

Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease.

There was statistically significant positive association between high anti-tTG titer and Marsh grading as 82% of patients with Marsh III had high anti-tTG titer (Chi2 18.5; P value 0.00; Odds Ratio 8.5).

The fraction of patients with Marsh III who were correctly identified as positive by anti-tTG titer ≥ 180 U/mL was high (sensitivity = 81.6).

Moreover, the fraction of patients with anti-tTG titer ≥ 180 U/mL who had Marsh III was also high (positive predictive value = 78.4).

Conclusion.

Anti-tTG titer ≥ 180 U/mL had significant positive association with Marsh III histopathological changes of celiac disease.

American Psychological Association (APA)

Hawamdeh, Hasan& Al-Zoubi, Basim& Al Sharqi, Yasameen& Qasrawi, Ayman& Abdelaziz, Yousef& Barbar, Maha. 2016. Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104752

Modern Language Association (MLA)

Hawamdeh, Hasan…[et al.]. Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104752

American Medical Association (AMA)

Hawamdeh, Hasan& Al-Zoubi, Basim& Al Sharqi, Yasameen& Qasrawi, Ayman& Abdelaziz, Yousef& Barbar, Maha. Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104752

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1104752