Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Wang, Xiao-Jie
Zheng, Zheng-Rong
Chi, Pan
Lin, Hui-Ming
Lu, Xing-Rong
Huang, Ying
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate the influence of interval between neoadjuvant chemoradiotherapy (NCRT) and surgery on oncological outcome.
Methods.
A systematic search was conducted in PubMed, the Cochrane Library, and Embase databases for publications reporting oncological outcomes of patients following rectal cancer surgery performed at different NCRT-surgery intervals.
Relative risk (RR) of pathological complete response (pCR) among different intervals was pooled.
Results.
Fifteen retrospective cohort studies representing 4431 patients met the inclusion criteria.
There was a significantly increased rate of pCR in patients treated with surgery followed 7 or 8 weeks later (RR, 1.45; 95% CI, 1.18–1.78; and P < 0.01 and RR, 1.49; 95% CI, 1.15–1.92; and P = 0.002 , resp.).
There is no consistent evidence of improved local control or overall survival with longer or shorter intervals.
Conclusion.
Performing surgery 7-8 weeks after the end of NCRT results in the highest chance of achieving pCR.
For candidates of abdominoperineal resection before NCRT, these data support implementation of prolonging the interval after NCRT to optimize the chances of pCR and perhaps add to the possibility of ultimate organ preservation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiao-Jie& Zheng, Zheng-Rong& Chi, Pan& Lin, Hui-Ming& Lu, Xing-Rong& Huang, Ying. 2016. Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104754
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiao-Jie…[et al.]. Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1104754
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiao-Jie& Zheng, Zheng-Rong& Chi, Pan& Lin, Hui-Ming& Lu, Xing-Rong& Huang, Ying. Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104754
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104754
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر