Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Xiao-Jie
Zheng, Zheng-Rong
Chi, Pan
Lin, Hui-Ming
Lu, Xing-Rong
Huang, Ying
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aim.
To evaluate the influence of interval between neoadjuvant chemoradiotherapy (NCRT) and surgery on oncological outcome.
Methods.
A systematic search was conducted in PubMed, the Cochrane Library, and Embase databases for publications reporting oncological outcomes of patients following rectal cancer surgery performed at different NCRT-surgery intervals.
Relative risk (RR) of pathological complete response (pCR) among different intervals was pooled.
Results.
Fifteen retrospective cohort studies representing 4431 patients met the inclusion criteria.
There was a significantly increased rate of pCR in patients treated with surgery followed 7 or 8 weeks later (RR, 1.45; 95% CI, 1.18–1.78; and P < 0.01 and RR, 1.49; 95% CI, 1.15–1.92; and P = 0.002 , resp.).
There is no consistent evidence of improved local control or overall survival with longer or shorter intervals.
Conclusion.
Performing surgery 7-8 weeks after the end of NCRT results in the highest chance of achieving pCR.
For candidates of abdominoperineal resection before NCRT, these data support implementation of prolonging the interval after NCRT to optimize the chances of pCR and perhaps add to the possibility of ultimate organ preservation.
American Psychological Association (APA)
Wang, Xiao-Jie& Zheng, Zheng-Rong& Chi, Pan& Lin, Hui-Ming& Lu, Xing-Rong& Huang, Ying. 2016. Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104754
Modern Language Association (MLA)
Wang, Xiao-Jie…[et al.]. Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1104754
American Medical Association (AMA)
Wang, Xiao-Jie& Zheng, Zheng-Rong& Chi, Pan& Lin, Hui-Ming& Lu, Xing-Rong& Huang, Ying. Effect of Interval between Neoadjuvant Chemoradiotherapy and Surgery on Oncological Outcome for Rectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104754