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Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation
المؤلفون المشاركون
Oltean, Mihai
Barrenäs, Christian
Martins, Paulo Ney
Herlenius, Gustaf
Gustafsson, Bengt
Bennet, William
Friman, Styrbjörn
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Exogenous bilirubin may reduce experimental ischemia-reperfusion injury (IRI) due to its antioxidant properties.
We studied if early graft exposure to high bilirubin levels in the recipient affects the early IRI and outcomes after liver transplantation (LTx).
Methods.
In 427 LTx patients, the AUROC curve based on bilirubin and AST at day 1 identified a cutoff of 2.04 mg/dL for the recipient pretransplant bilirubin.
Recipients were grouped as having low (group L, n=152) or high (group H, n=275) bilirubin.
Both groups had similar donor-related variables (age, preservation time, donor BMI > 28, and donor risk index (DRI)).
Results.
Alanine (ALT) and aspartate (AST) aminotransferase levels were higher in group L at day 1; ALT levels remained higher at day 2 in group L.
LTx from high risk donors (DRI > 2) revealed a trend towards lower transaminases during the first two days after transplantation in group H.
One month and 1-year patient survival were similar in groups L and H.
High preoperative bilirubin did not affect the risk for early graft dysfunction (EGD), death, or graft loss during the first year after transplantation nor the incidence of acute rejection.
LTx using donors with DRI > 2 resulted in similar rates of EGD in both groups.
Conclusion.
Increased bilirubin appears to reduce the early IRI after LTx yet this improvement was insufficient to improve the clinical outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oltean, Mihai& Barrenäs, Christian& Martins, Paulo Ney& Herlenius, Gustaf& Gustafsson, Bengt& Friman, Styrbjörn…[et al.]. 2016. Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oltean, Mihai…[et al.]. Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oltean, Mihai& Barrenäs, Christian& Martins, Paulo Ney& Herlenius, Gustaf& Gustafsson, Bengt& Friman, Styrbjörn…[et al.]. Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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