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Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation
Joint Authors
Oltean, Mihai
Barrenäs, Christian
Martins, Paulo Ney
Herlenius, Gustaf
Gustafsson, Bengt
Bennet, William
Friman, Styrbjörn
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Exogenous bilirubin may reduce experimental ischemia-reperfusion injury (IRI) due to its antioxidant properties.
We studied if early graft exposure to high bilirubin levels in the recipient affects the early IRI and outcomes after liver transplantation (LTx).
Methods.
In 427 LTx patients, the AUROC curve based on bilirubin and AST at day 1 identified a cutoff of 2.04 mg/dL for the recipient pretransplant bilirubin.
Recipients were grouped as having low (group L, n=152) or high (group H, n=275) bilirubin.
Both groups had similar donor-related variables (age, preservation time, donor BMI > 28, and donor risk index (DRI)).
Results.
Alanine (ALT) and aspartate (AST) aminotransferase levels were higher in group L at day 1; ALT levels remained higher at day 2 in group L.
LTx from high risk donors (DRI > 2) revealed a trend towards lower transaminases during the first two days after transplantation in group H.
One month and 1-year patient survival were similar in groups L and H.
High preoperative bilirubin did not affect the risk for early graft dysfunction (EGD), death, or graft loss during the first year after transplantation nor the incidence of acute rejection.
LTx using donors with DRI > 2 resulted in similar rates of EGD in both groups.
Conclusion.
Increased bilirubin appears to reduce the early IRI after LTx yet this improvement was insufficient to improve the clinical outcome.
American Psychological Association (APA)
Oltean, Mihai& Barrenäs, Christian& Martins, Paulo Ney& Herlenius, Gustaf& Gustafsson, Bengt& Friman, Styrbjörn…[et al.]. 2016. Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104765
Modern Language Association (MLA)
Oltean, Mihai…[et al.]. Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104765
American Medical Association (AMA)
Oltean, Mihai& Barrenäs, Christian& Martins, Paulo Ney& Herlenius, Gustaf& Gustafsson, Bengt& Friman, Styrbjörn…[et al.]. Recipient Hyperbilirubinemia May Reduce Ischemia-Reperfusion Injury but Fails to Improve Outcome in Clinical Liver Transplantation. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104765