Clinical Impact of Viral Load on the Development of Hepatocellular Carcinoma and Liver-Related Mortality in Patients with Hepatitis C Virus Infection
المؤلفون المشاركون
Noh, Ran
Lee, Doo Hyuck
Kwon, Byoung Woon
Kim, Yong Hyun
Kim, Suk Bae
Song, Il Han
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
This study aimed to assess clinical impact of hepatitis C viral load on the development of hepatocellular carcinoma (HCC) and liver-related mortality in HCV-infected patients.
Methods.
A total of 111 subjects with chronic HCV infection who were available for serum quantitation of HCV RNA were recruited in this retrospective cohort.
Cox-proportional hazards models were used to calculate hazard ratio (HR) of developing HCC and liver-related mortality according to serum HCV RNA titers.
Results.
HCC was developed in 14 patients during follow-up period.
The cumulative risk of HCC development was higher in subjects with high HCV RNA titer (log HCV RNA IU/mL > 6) than subjects with low titer (log HCV RNA IU/mL ≦ 6) (HR = 4.63, P = 0.032 ), giving an incidence rate of 474.1 and 111.5 per 10,000 person-years, respectively.
Old age (HR = 9.71, P = 0.014 ), accompanying cirrhosis (HR = 19.34, P = 0.004 ), and low platelet count (HR = 13.97, P = 0.009 ) were other independent risk factors for the development of HCC.
Liver-related death occurred in 7 patients.
Accompanying cirrhosis (HR = 6.13, P = 0.012 ) and low albumin level (HR = 9.17, P = 0.002 ), but not HCV RNA titer, were significant risk factors related to liver-related mortality.
Conclusion.
Serum HCV RNA titer may be considered an independent risk factor for the development of HCC but not liver-related mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Noh, Ran& Lee, Doo Hyuck& Kwon, Byoung Woon& Kim, Yong Hyun& Kim, Suk Bae& Song, Il Han. 2016. Clinical Impact of Viral Load on the Development of Hepatocellular Carcinoma and Liver-Related Mortality in Patients with Hepatitis C Virus Infection. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104779
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Noh, Ran…[et al.]. Clinical Impact of Viral Load on the Development of Hepatocellular Carcinoma and Liver-Related Mortality in Patients with Hepatitis C Virus Infection. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104779
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Noh, Ran& Lee, Doo Hyuck& Kwon, Byoung Woon& Kim, Yong Hyun& Kim, Suk Bae& Song, Il Han. Clinical Impact of Viral Load on the Development of Hepatocellular Carcinoma and Liver-Related Mortality in Patients with Hepatitis C Virus Infection. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104779
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104779
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر