Clinical Impact of Viral Load on the Development of Hepatocellular Carcinoma and Liver-Related Mortality in Patients with Hepatitis C Virus Infection

Abstract EN

Aim.

This study aimed to assess clinical impact of hepatitis C viral load on the development of hepatocellular carcinoma (HCC) and liver-related mortality in HCV-infected patients.

Methods.

A total of 111 subjects with chronic HCV infection who were available for serum quantitation of HCV RNA were recruited in this retrospective cohort.

Cox-proportional hazards models were used to calculate hazard ratio (HR) of developing HCC and liver-related mortality according to serum HCV RNA titers.

Results.

HCC was developed in 14 patients during follow-up period.

The cumulative risk of HCC development was higher in subjects with high HCV RNA titer (log HCV RNA IU/mL > 6) than subjects with low titer (log HCV RNA IU/mL ≦ 6) (HR = 4.63, P = 0.032 ), giving an incidence rate of 474.1 and 111.5 per 10,000 person-years, respectively.

Old age (HR = 9.71, P = 0.014 ), accompanying cirrhosis (HR = 19.34, P = 0.004 ), and low platelet count (HR = 13.97, P = 0.009 ) were other independent risk factors for the development of HCC.

Liver-related death occurred in 7 patients.

Accompanying cirrhosis (HR = 6.13, P = 0.012 ) and low albumin level (HR = 9.17, P = 0.002 ), but not HCV RNA titer, were significant risk factors related to liver-related mortality.

Conclusion.

Serum HCV RNA titer may be considered an independent risk factor for the development of HCC but not liver-related mortality.