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Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis
المؤلفون المشاركون
Zhang, Jing
Wang, Ye
Shi, Yanyan
Wei, Ying
Zhang, Ting
Ding, Shigang
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Pathologic duodenogastric reflux can induce or aggravate gastritis because of the presence of bile acids.
Bile reflux has been generally considered to be associated with intestinal metaplasia and gastric cancer.
However, the pathogenic mechanisms of the effects of bile acids on gastric mucosa are still unknown.
Methods.
To explore the mechanisms by which bile acids induce gastric mucosal lesions, we examined cell apoptosis in the gastric epithelial cell line GES-1 and investigated the changes in protein profiles of GES-1 cells in response to a bile acid deoxycholic acid using a proteomics approach.
Changes in the profiles of the differently expressed proteins were analyzed using the DAVID and STRING programs.
Results.
We found apoptosis was significantly induced in GES-1 cells by deoxycholic acid.
Using liquid chromatographic/tandem mass spectrometric (LC-MS/MS) methods, 134 upregulated proteins and 214 downregulated proteins were identified in the bile acid treated GES-1 cells.
Bioinformatics analysis revealed the interactions and signaling networks of these differentially expressed proteins.
Conclusion.
These findings may improve the understanding of the molecular mechanisms underlying the pathogenicity of bile acids on gastric mucosa.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Yanyan& Wei, Ying& Zhang, Ting& Zhang, Jing& Wang, Ye& Ding, Shigang. 2016. Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104846
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Yanyan…[et al.]. Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1104846
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Yanyan& Wei, Ying& Zhang, Ting& Zhang, Jing& Wang, Ye& Ding, Shigang. Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104846
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104846
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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