Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients
المؤلفون المشاركون
Shiga, Kazuyoshi
Hara, Masayasu
Nagasaki, Takaya
Sato, Takafumi
Takahashi, Hiroki
Sato, Mikinori
Takeyama, Hiromitsu
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
To evaluate the prognostic significance of serum interleukin-6 (IL-6) in colorectal cancer (CRC).
Patients and Methods.
Preoperative serum IL-6 was measured in 233 CRC patients and 13 healthy controls.
Relationships between IL-6 and various clinicopathological factors were evaluated, and the overall survival (OS) and disease-free survival (DFS) rates according to IL-6 status were calculated for all patients and according to disease stage.
Results.
The mean IL-6 level was 6.6 pg/mL in CRC patients and 2.6 pg/mL in healthy controls.
Using a cutoff of 6.3 pg/mL, obtained using receiver operating characteristic curve analysis, 57 patients had a high IL-6 level.
The mean value was higher for stage II disease than for stage III disease.
IL-6 status correlated with C-reactive protein (CRP) and carcinoembryonic antigen levels, obstruction, and pT4 disease.
The OS differed according to the IL-6 status for all patients, whereas the DFS differed for all patients and for those with stage II disease.
The Cox proportional hazards model showed that pT4 disease was an independent risk factor for recurrence in all CRC patients; IL-6, CRP, and pT4 were significant risk factors in stage II patients.
Conclusions.
The preoperative IL-6 level influences the risk of CRC recurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shiga, Kazuyoshi& Hara, Masayasu& Nagasaki, Takaya& Sato, Takafumi& Takahashi, Hiroki& Sato, Mikinori…[et al.]. 2015. Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shiga, Kazuyoshi…[et al.]. Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shiga, Kazuyoshi& Hara, Masayasu& Nagasaki, Takaya& Sato, Takafumi& Takahashi, Hiroki& Sato, Mikinori…[et al.]. Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر