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Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients
Joint Authors
Shiga, Kazuyoshi
Hara, Masayasu
Nagasaki, Takaya
Sato, Takafumi
Takahashi, Hiroki
Sato, Mikinori
Takeyama, Hiromitsu
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
To evaluate the prognostic significance of serum interleukin-6 (IL-6) in colorectal cancer (CRC).
Patients and Methods.
Preoperative serum IL-6 was measured in 233 CRC patients and 13 healthy controls.
Relationships between IL-6 and various clinicopathological factors were evaluated, and the overall survival (OS) and disease-free survival (DFS) rates according to IL-6 status were calculated for all patients and according to disease stage.
Results.
The mean IL-6 level was 6.6 pg/mL in CRC patients and 2.6 pg/mL in healthy controls.
Using a cutoff of 6.3 pg/mL, obtained using receiver operating characteristic curve analysis, 57 patients had a high IL-6 level.
The mean value was higher for stage II disease than for stage III disease.
IL-6 status correlated with C-reactive protein (CRP) and carcinoembryonic antigen levels, obstruction, and pT4 disease.
The OS differed according to the IL-6 status for all patients, whereas the DFS differed for all patients and for those with stage II disease.
The Cox proportional hazards model showed that pT4 disease was an independent risk factor for recurrence in all CRC patients; IL-6, CRP, and pT4 were significant risk factors in stage II patients.
Conclusions.
The preoperative IL-6 level influences the risk of CRC recurrence.
American Psychological Association (APA)
Shiga, Kazuyoshi& Hara, Masayasu& Nagasaki, Takaya& Sato, Takafumi& Takahashi, Hiroki& Sato, Mikinori…[et al.]. 2015. Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104853
Modern Language Association (MLA)
Shiga, Kazuyoshi…[et al.]. Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104853
American Medical Association (AMA)
Shiga, Kazuyoshi& Hara, Masayasu& Nagasaki, Takaya& Sato, Takafumi& Takahashi, Hiroki& Sato, Mikinori…[et al.]. Preoperative Serum Interleukin-6 Is a Potential Prognostic Factor for Colorectal Cancer, including Stage II Patients. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104853