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Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations
المؤلفون المشاركون
Rider, Peleg
Carmi, Yaron
Cohen, Idan
المصدر
International Journal of Cell Biology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Proinflammatory cytokines are potent mediators of numerous biological processes and are tightly regulated in the body.
Chronic uncontrolled levels of such cytokines can initiate and derive many pathologies, including incidences of autoimmunity and cancer.
Therefore, therapies that regulate the activity of inflammatory cytokines, either by supplementation of anti-inflammatory recombinant cytokines or by neutralizing them by using blocking antibodies, have been extensively used over the past decades.
Over the past few years, new innovative biological agents for blocking and regulating cytokine activities have emerged.
Here, we review some of the most recent approaches of cytokine targeting, focusing on anti-TNF antibodies or recombinant TNF decoy receptor, recombinant IL-1 receptor antagonist (IL-1Ra) and anti-IL-1 antibodies, anti-IL-6 receptor antibodies, and TH17 targeting antibodies.
We discuss their effects as biologic drugs, as evaluated in numerous clinical trials, and highlight their therapeutic potential as well as emphasize their inherent limitations and clinical risks.
We suggest that while systemic blocking of proinflammatory cytokines using biological agents can ameliorate disease pathogenesis and progression, it may also abrogate the hosts defense against infections.
Moreover, we outline the rational need to develop new therapies, which block inflammatory cytokines only at sites of inflammation, while enabling their function systemically.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rider, Peleg& Carmi, Yaron& Cohen, Idan. 2016. Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. International Journal of Cell Biology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105510
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rider, Peleg…[et al.]. Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. International Journal of Cell Biology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1105510
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rider, Peleg& Carmi, Yaron& Cohen, Idan. Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations. International Journal of Cell Biology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105510
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105510
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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