The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity
المؤلفون المشاركون
Tambo, Amos
Roshan, Mohsin H. K.
Pace, Nikolai P.
المصدر
International Journal of Chronic Diseases
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The global obesity epidemic, dubbed “globesity” by the World Health Organisation, is a pressing public health issue.
The aetiology of obesity is multifactorial incorporating both genetic and environmental factors.
Recently, epidemiological studies have observed an association between microbes and obesity.
Obesity-promoting microbiome and resultant gut barrier disintegration have been implicated as key factors facilitating metabolic endotoxaemia.
This is an influx of bacterial endotoxins into the systemic circulation, believed to underpin obesity pathogenesis.
Adipocyte dysfunction and subsequent adipokine secretion characterised by low grade inflammation, were conventionally attributed to persistent hyperlipidaemia.
They were thought of as pivotal in perpetuating obesity.
It is now debated whether infection and endotoxaemia are also implicated in initiating and perpetuating low grade inflammation.
The fact that obesity has a prevalence of over 600 million and serves as a risk factor for chronic diseases including cardiovascular disease and type 2 diabetes mellitus is testament to the importance of exploring the role of microbes in obesity pathobiology.
It is on this basis that Massachusetts General Hospital is sponsoring the Faecal Microbiota Transplant for Obesity and Metabolism clinical trial, to study the impact of microbiome composition on weight.
The association of microbes with obesity, namely, adenovirus infection and metabolic endotoxaemia, is reviewed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tambo, Amos& Roshan, Mohsin H. K.& Pace, Nikolai P.. 2016. The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity. International Journal of Chronic Diseases،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105525
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tambo, Amos…[et al.]. The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity. International Journal of Chronic Diseases No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1105525
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tambo, Amos& Roshan, Mohsin H. K.& Pace, Nikolai P.. The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity. International Journal of Chronic Diseases. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105525
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105525
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر