The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity

Joint Authors

Tambo, Amos
Roshan, Mohsin H. K.
Pace, Nikolai P.

Source

International Journal of Chronic Diseases

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-11-24

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases
Medicine

Abstract EN

The global obesity epidemic, dubbed “globesity” by the World Health Organisation, is a pressing public health issue.

The aetiology of obesity is multifactorial incorporating both genetic and environmental factors.

Recently, epidemiological studies have observed an association between microbes and obesity.

Obesity-promoting microbiome and resultant gut barrier disintegration have been implicated as key factors facilitating metabolic endotoxaemia.

This is an influx of bacterial endotoxins into the systemic circulation, believed to underpin obesity pathogenesis.

Adipocyte dysfunction and subsequent adipokine secretion characterised by low grade inflammation, were conventionally attributed to persistent hyperlipidaemia.

They were thought of as pivotal in perpetuating obesity.

It is now debated whether infection and endotoxaemia are also implicated in initiating and perpetuating low grade inflammation.

The fact that obesity has a prevalence of over 600 million and serves as a risk factor for chronic diseases including cardiovascular disease and type 2 diabetes mellitus is testament to the importance of exploring the role of microbes in obesity pathobiology.

It is on this basis that Massachusetts General Hospital is sponsoring the Faecal Microbiota Transplant for Obesity and Metabolism clinical trial, to study the impact of microbiome composition on weight.

The association of microbes with obesity, namely, adenovirus infection and metabolic endotoxaemia, is reviewed.

American Psychological Association (APA)

Tambo, Amos& Roshan, Mohsin H. K.& Pace, Nikolai P.. 2016. The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity. International Journal of Chronic Diseases،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105525

Modern Language Association (MLA)

Tambo, Amos…[et al.]. The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity. International Journal of Chronic Diseases No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1105525

American Medical Association (AMA)

Tambo, Amos& Roshan, Mohsin H. K.& Pace, Nikolai P.. The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity. International Journal of Chronic Diseases. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105525

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1105525