Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience
المؤلفون المشاركون
Maiorano, Eugenio
Crincoli, Vito
Limongelli, Luisa
Tempesta, Angela
Favia, Gianfranco
المصدر
International Journal of Dentistry
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies for bone neoplastic localizations and osteoporosis.
The aim of this study was to evaluate the clinicopathological features of MRONJ in a cohort of patients treated by new antiresorptive drugs (denosumab) and the corresponding outcome after 13-year maximum follow-up.
Overall, 244 patients affected by MRONJ were treated from 2003 to 2015.
After clinical and radiological examinations, all lesions were staged according to a dimensional staging system and then surgically treated.
All the denosumab-related lesions were classified as stage II or III, thus requiring a more or less invasive surgical approach, despite the results of many recent studies, which suggested a conservative medical approach with early resolution for MRONJ in patients on denosumab.
In the current series, 86.9% of treated lesions showed complete clinical and radiological healing, while 13.1% recurred; all recurrences were detected in patients who could not interrupt chemotherapy, steroids, and/or antiresorptive drugs administration due to their general conditions.
In conclusion, all oral specialists should be aware of the MRONJ risk among patients taking new antiresorptive drugs; moreover, our protocol based on surgical treatment guided by dimensional staging could be considered effective in view of the low recurrence rate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Favia, Gianfranco& Tempesta, Angela& Limongelli, Luisa& Crincoli, Vito& Maiorano, Eugenio. 2016. Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience. International Journal of Dentistry،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Favia, Gianfranco…[et al.]. Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience. International Journal of Dentistry No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Favia, Gianfranco& Tempesta, Angela& Limongelli, Luisa& Crincoli, Vito& Maiorano, Eugenio. Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience. International Journal of Dentistry. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر