Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience
Joint Authors
Maiorano, Eugenio
Crincoli, Vito
Limongelli, Luisa
Tempesta, Angela
Favia, Gianfranco
Source
International Journal of Dentistry
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies for bone neoplastic localizations and osteoporosis.
The aim of this study was to evaluate the clinicopathological features of MRONJ in a cohort of patients treated by new antiresorptive drugs (denosumab) and the corresponding outcome after 13-year maximum follow-up.
Overall, 244 patients affected by MRONJ were treated from 2003 to 2015.
After clinical and radiological examinations, all lesions were staged according to a dimensional staging system and then surgically treated.
All the denosumab-related lesions were classified as stage II or III, thus requiring a more or less invasive surgical approach, despite the results of many recent studies, which suggested a conservative medical approach with early resolution for MRONJ in patients on denosumab.
In the current series, 86.9% of treated lesions showed complete clinical and radiological healing, while 13.1% recurred; all recurrences were detected in patients who could not interrupt chemotherapy, steroids, and/or antiresorptive drugs administration due to their general conditions.
In conclusion, all oral specialists should be aware of the MRONJ risk among patients taking new antiresorptive drugs; moreover, our protocol based on surgical treatment guided by dimensional staging could be considered effective in view of the low recurrence rate.
American Psychological Association (APA)
Favia, Gianfranco& Tempesta, Angela& Limongelli, Luisa& Crincoli, Vito& Maiorano, Eugenio. 2016. Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience. International Journal of Dentistry،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105607
Modern Language Association (MLA)
Favia, Gianfranco…[et al.]. Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience. International Journal of Dentistry No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105607
American Medical Association (AMA)
Favia, Gianfranco& Tempesta, Angela& Limongelli, Luisa& Crincoli, Vito& Maiorano, Eugenio. Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience. International Journal of Dentistry. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105607