Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences
المؤلفون المشاركون
Giandalia, Annalisa
Muscianisi, Marco
Nunziata, Morabito
Ruffo, Maria Concetta
Catalano, Antonino
Russo, Giuseppina T.
Cucinotta, Domenico
Romeo, Elisabetta L.
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic fractures, resulting in disabilities and increased mortality.
The pathophysiological mechanisms linking diabetes to osteoporosis have not been fully explained, but alterations in bone structure and quality are well described in diabetic subjects, likely due to a combination of different factors.
Insulin deficiency and dysfunction, obesity and hyperinsulinemia, altered level of oestrogen, leptin, and adiponectin as well as diabetes-related complications, especially peripheral neuropathy, orthostatic hypotension, or reduced vision due to retinopathy may all be associated with an impairment in bone metabolism and with the increased risk of fractures.
Finally, medications commonly used in the treatment of T2DM may have an impact on bone metabolism and on fracture risk, particularly in postmenopausal women.
When considering the impact of hypoglycaemic drugs on bone, it is important to balance their potential direct effects on bone quality with the risk of falling-related fractures due to the associated hypoglycaemic risk.
In this review, experimental and clinical evidence connecting bone metabolism and fracture risk to T2DM is discussed, with particular emphasis on hypoglycaemic treatments and gender-specific implications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Russo, Giuseppina T.& Giandalia, Annalisa& Romeo, Elisabetta L.& Nunziata, Morabito& Muscianisi, Marco& Ruffo, Maria Concetta…[et al.]. 2016. Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105762
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Russo, Giuseppina T.…[et al.]. Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences. International Journal of Endocrinology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1105762
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Russo, Giuseppina T.& Giandalia, Annalisa& Romeo, Elisabetta L.& Nunziata, Morabito& Muscianisi, Marco& Ruffo, Maria Concetta…[et al.]. Fracture Risk in Type 2 Diabetes: Current Perspectives and Gender Differences. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1105762
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105762
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر