FGF21 Is Associated with Acanthosis Nigricans in Obese Patients
المؤلفون المشاركون
Cheng, Xiaoyun
Song, Kexiu
Bu, Le
Qu, Shen
Wang, XingChun
Chen, Jiaqi
Huang, Yueye
Yang, Jie
Li, Yan
Wang, Jiying
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
We aimed to investigate the relationship between FGF21 and obesity-related acanthosis nigricans (AN).
Methods.
40 obese patients without AN (OB group), 40 obese patients with AN (AN group), and 40 healthy volunteers (control group, CON) were included in this study.
Weight, BMI, lipid profile, FFA, UA, and CRP were measured in all participants.
Oral glucose tolerance tests (OGTT) were performed and serum glucose and plasma insulin were measured.
Serum FGF21 was measured by ELISA.
Results.
Compared with OB group, AN group had higher levels of fasting insulin and homeostasis model of assessment for insulin resistance (HOMA-IR) (P<0.05), but lower serum levels of blood glucose.
The difference of FGF21 among three groups was significant and AN group showed the highest serum level of FGF21 (P<0.05).
Serum FGF21 was most positively correlated with fasting insulin and HOMA-IR.
Multiple logistic analysis showed that FGF21 was the independent risk factor for AN (OR 4.550; 95% CI 1.054–19.635; P=0.042).
Conclusion.
AN patients had more serious hyperinsulinemia but better serum levels of blood glucose than OB.
Increased FGF21 is associated with AN in obese patients and may be considered as compensatory response to the decreased insulin sensitivity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yueye& Yang, Jie& Li, Yan& Chen, Jiaqi& Song, Kexiu& Wang, XingChun…[et al.]. 2016. FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105763
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yueye…[et al.]. FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105763
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yueye& Yang, Jie& Li, Yan& Chen, Jiaqi& Song, Kexiu& Wang, XingChun…[et al.]. FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105763
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105763
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر