FGF21 Is Associated with Acanthosis Nigricans in Obese Patients
Joint Authors
Cheng, Xiaoyun
Song, Kexiu
Bu, Le
Qu, Shen
Wang, XingChun
Chen, Jiaqi
Huang, Yueye
Yang, Jie
Li, Yan
Wang, Jiying
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
We aimed to investigate the relationship between FGF21 and obesity-related acanthosis nigricans (AN).
Methods.
40 obese patients without AN (OB group), 40 obese patients with AN (AN group), and 40 healthy volunteers (control group, CON) were included in this study.
Weight, BMI, lipid profile, FFA, UA, and CRP were measured in all participants.
Oral glucose tolerance tests (OGTT) were performed and serum glucose and plasma insulin were measured.
Serum FGF21 was measured by ELISA.
Results.
Compared with OB group, AN group had higher levels of fasting insulin and homeostasis model of assessment for insulin resistance (HOMA-IR) (P<0.05), but lower serum levels of blood glucose.
The difference of FGF21 among three groups was significant and AN group showed the highest serum level of FGF21 (P<0.05).
Serum FGF21 was most positively correlated with fasting insulin and HOMA-IR.
Multiple logistic analysis showed that FGF21 was the independent risk factor for AN (OR 4.550; 95% CI 1.054–19.635; P=0.042).
Conclusion.
AN patients had more serious hyperinsulinemia but better serum levels of blood glucose than OB.
Increased FGF21 is associated with AN in obese patients and may be considered as compensatory response to the decreased insulin sensitivity.
American Psychological Association (APA)
Huang, Yueye& Yang, Jie& Li, Yan& Chen, Jiaqi& Song, Kexiu& Wang, XingChun…[et al.]. 2016. FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105763
Modern Language Association (MLA)
Huang, Yueye…[et al.]. FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105763
American Medical Association (AMA)
Huang, Yueye& Yang, Jie& Li, Yan& Chen, Jiaqi& Song, Kexiu& Wang, XingChun…[et al.]. FGF21 Is Associated with Acanthosis Nigricans in Obese Patients. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105763