The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Shao, Jiaqing
Peng, Li
Xu, Yixin
Li, Jie
Wang, Yangtian
Du, Hong
Liu, Zhimin
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-24
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Background.
p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
This study aimed to examine p38 MAPK activation in DN and determine whether beraprost sodium (BPS) ameliorates DN by inhibiting inflammation and p38 MAPK signaling pathway in diabetic rats.
Methods.
Forty male Sprague Dawley (SD) rats were randomly divided into the normal control group, type 2 diabetic group, and BPS treatment group.
At the end of the 8-week experiment, we measured renal pathological changes and the activation of the p38 MAPK signaling pathway and inflammation.
Result.
After BPS treatment, renal function, 24-hour urine protein, lipid profiles, and blood glucose level were improved significantly; meanwhile, inflammation and the expression of p38 MAPK signaling pathway in the diabetic kidney were attenuated.
Conclusions.
BPS significantly prevented type 2 diabetes induced kidney injury characterized by renal dysfunction and pathological changes.
The protective mechanisms are complicated but may be mainly attributed to the inhibition of the p38 MAPK signaling pathway and inflammation in the diabetic kidney.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Li& Li, Jie& Xu, Yixin& Wang, Yangtian& Du, Hong& Shao, Jiaqing…[et al.]. 2016. The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1105775
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Li…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats. International Journal of Endocrinology No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1105775
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Li& Li, Jie& Xu, Yixin& Wang, Yangtian& Du, Hong& Shao, Jiaqing…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1105775
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105775
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر