The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats
Joint Authors
Shao, Jiaqing
Peng, Li
Xu, Yixin
Li, Jie
Wang, Yangtian
Du, Hong
Liu, Zhimin
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-24
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Background.
p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN).
This study aimed to examine p38 MAPK activation in DN and determine whether beraprost sodium (BPS) ameliorates DN by inhibiting inflammation and p38 MAPK signaling pathway in diabetic rats.
Methods.
Forty male Sprague Dawley (SD) rats were randomly divided into the normal control group, type 2 diabetic group, and BPS treatment group.
At the end of the 8-week experiment, we measured renal pathological changes and the activation of the p38 MAPK signaling pathway and inflammation.
Result.
After BPS treatment, renal function, 24-hour urine protein, lipid profiles, and blood glucose level were improved significantly; meanwhile, inflammation and the expression of p38 MAPK signaling pathway in the diabetic kidney were attenuated.
Conclusions.
BPS significantly prevented type 2 diabetes induced kidney injury characterized by renal dysfunction and pathological changes.
The protective mechanisms are complicated but may be mainly attributed to the inhibition of the p38 MAPK signaling pathway and inflammation in the diabetic kidney.
American Psychological Association (APA)
Peng, Li& Li, Jie& Xu, Yixin& Wang, Yangtian& Du, Hong& Shao, Jiaqing…[et al.]. 2016. The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1105775
Modern Language Association (MLA)
Peng, Li…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats. International Journal of Endocrinology No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1105775
American Medical Association (AMA)
Peng, Li& Li, Jie& Xu, Yixin& Wang, Yangtian& Du, Hong& Shao, Jiaqing…[et al.]. The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat DietStreptozotocin-Induced Diabetic Rats. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1105775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105775