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Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy
المؤلفون المشاركون
Geng, Xiaojing
Dong, Jun
Liang, Ying
Deng, Yajuan
Li, Ting
Luo, Tongfeng
Lin, Hailun
Zhang, Shaoling
Yan, Li
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Adrenal aldosterone-producing adenoma (APA), producing the salt-retaining hormone aldosterone, commonly causes secondary hypertension, which often persists after unilateral adrenalectomy.
Although persistent hypertension was correlated with residual hormone aldosterone, the in vivo mechanism remains unclear.
NADPH oxidase is the critical cause of aldosterone synthesis in vitro.
Nox2 and p22phox comprise the NADPH oxidase catalytic core, serving to initiate a reactive oxygen species (ROS) cascade that may participate in the pathology.
mRNAs of seven NADPH oxidase isoforms in APA were evaluated by RT-PCR and Q-PCR and their proteins by immunohistochemistry and Western blotting.
NADPH oxidase activity was also detected.
Nox2 and p22phox were especially abundant in APA.
Particularly higher Nox2 and p22phox gene and protein levels were seen in APA than controls.
Significant correlations between Nox2 mRNA and aldosterone synthase (CYP11B2) mRNA ( R = 0.66 , P < 0.01 ) and Nox2 protein and baseline plasma aldosterone concentration (PAC) ( R = 0.503 , P < 0.01 ) were detected in APA; however, none were found between p22phox mRNA, CYP11B2 mRNA, p22phox protein, and baseline PAC.
Importantly, we found that Nox2 localized specifically in hyperplastic zona glomerulosa cells.
In conclusion, our results highlight that Nox2 and p22phox may be directly involved in pathological aldosterone production and zona glomerulosa cell proliferation after APA resection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Geng, Xiaojing& Yan, Li& Dong, Jun& Liang, Ying& Deng, Yajuan& Li, Ting…[et al.]. 2016. Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105822
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Geng, Xiaojing…[et al.]. Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. International Journal of Endocrinology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1105822
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Geng, Xiaojing& Yan, Li& Dong, Jun& Liang, Ying& Deng, Yajuan& Li, Ting…[et al.]. Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105822
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105822
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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