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Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy
Joint Authors
Geng, Xiaojing
Dong, Jun
Liang, Ying
Deng, Yajuan
Li, Ting
Luo, Tongfeng
Lin, Hailun
Zhang, Shaoling
Yan, Li
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Adrenal aldosterone-producing adenoma (APA), producing the salt-retaining hormone aldosterone, commonly causes secondary hypertension, which often persists after unilateral adrenalectomy.
Although persistent hypertension was correlated with residual hormone aldosterone, the in vivo mechanism remains unclear.
NADPH oxidase is the critical cause of aldosterone synthesis in vitro.
Nox2 and p22phox comprise the NADPH oxidase catalytic core, serving to initiate a reactive oxygen species (ROS) cascade that may participate in the pathology.
mRNAs of seven NADPH oxidase isoforms in APA were evaluated by RT-PCR and Q-PCR and their proteins by immunohistochemistry and Western blotting.
NADPH oxidase activity was also detected.
Nox2 and p22phox were especially abundant in APA.
Particularly higher Nox2 and p22phox gene and protein levels were seen in APA than controls.
Significant correlations between Nox2 mRNA and aldosterone synthase (CYP11B2) mRNA ( R = 0.66 , P < 0.01 ) and Nox2 protein and baseline plasma aldosterone concentration (PAC) ( R = 0.503 , P < 0.01 ) were detected in APA; however, none were found between p22phox mRNA, CYP11B2 mRNA, p22phox protein, and baseline PAC.
Importantly, we found that Nox2 localized specifically in hyperplastic zona glomerulosa cells.
In conclusion, our results highlight that Nox2 and p22phox may be directly involved in pathological aldosterone production and zona glomerulosa cell proliferation after APA resection.
American Psychological Association (APA)
Geng, Xiaojing& Yan, Li& Dong, Jun& Liang, Ying& Deng, Yajuan& Li, Ting…[et al.]. 2016. Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105822
Modern Language Association (MLA)
Geng, Xiaojing…[et al.]. Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. International Journal of Endocrinology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1105822
American Medical Association (AMA)
Geng, Xiaojing& Yan, Li& Dong, Jun& Liang, Ying& Deng, Yajuan& Li, Ting…[et al.]. Role of Nox2 and p22phox in Persistent Postoperative Hypertension in Aldosterone-Producing Adenoma Patients after Adrenalectomy. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105822
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105822