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Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome
المؤلفون المشاركون
Chiarelli, Francesco
Stagi, Stefano
Manoni, Cristina
de Martino, Maurizio
Lapi, Elisabetta
Giglio, Sabrina
Di Tommaso, Mariarosaria
Scalini, Perla
Dosa, Laura
Verrotti, Alberto
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Klinefelter syndrome (KS) has long-term consequences on bone health.
However, studies regarding bone status and metabolism during childhood and adolescence are very rare.
Patients.
This cross-sectional study involved 40 (mean age: 13.7 ± 3.8 years) KS children and adolescents and 80 age-matched healthy subjects.
For both patient and control groups, we evaluated serum levels of ionised and total calcium, phosphate, total testosterone, luteinising hormone, follicle stimulating hormone, parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D, osteocalcin, bone alkaline phosphatase, and urinary deoxypyridinoline concentrations.
We also calculated the z-scores of the phalangeal amplitude-dependent speed of sound (AD-SoS) and the bone transmission time (BTT).
Results.
KS children and adolescents showed significantly reduced AD-SoS ( p < 0.005 ) and BTT ( p < 0.0005 ) z-scores compared to the controls.
However, KS patients presented significantly higher PTH ( p < 0.0001 ) and significantly lower 25(OH)D ( p < 0.0001 ), osteocalcin ( p < 0.05 ), and bone alkaline phosphatase levels ( p < 0.005 ).
Interestingly, these metabolic bone disorders were already present in the prepubertal subjects.
Conclusions.
KS children and adolescents exhibited impaired bone mineral status and metabolism with higher PTH levels and a significant reduction of 25-OH-D and bone formation markers.
Interestingly, this impairment was already evident in prepubertal KS patients.
Follow-ups should be scheduled with KS patients to investigate and ameliorate bone mineral status and metabolism until the prepubertal ages.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stagi, Stefano& Di Tommaso, Mariarosaria& Manoni, Cristina& Scalini, Perla& Chiarelli, Francesco& Verrotti, Alberto…[et al.]. 2016. Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105835
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stagi, Stefano…[et al.]. Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105835
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stagi, Stefano& Di Tommaso, Mariarosaria& Manoni, Cristina& Scalini, Perla& Chiarelli, Francesco& Verrotti, Alberto…[et al.]. Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105835
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105835
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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