Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome
Joint Authors
Chiarelli, Francesco
Stagi, Stefano
Manoni, Cristina
de Martino, Maurizio
Lapi, Elisabetta
Giglio, Sabrina
Di Tommaso, Mariarosaria
Scalini, Perla
Dosa, Laura
Verrotti, Alberto
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Klinefelter syndrome (KS) has long-term consequences on bone health.
However, studies regarding bone status and metabolism during childhood and adolescence are very rare.
Patients.
This cross-sectional study involved 40 (mean age: 13.7 ± 3.8 years) KS children and adolescents and 80 age-matched healthy subjects.
For both patient and control groups, we evaluated serum levels of ionised and total calcium, phosphate, total testosterone, luteinising hormone, follicle stimulating hormone, parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D, osteocalcin, bone alkaline phosphatase, and urinary deoxypyridinoline concentrations.
We also calculated the z-scores of the phalangeal amplitude-dependent speed of sound (AD-SoS) and the bone transmission time (BTT).
Results.
KS children and adolescents showed significantly reduced AD-SoS ( p < 0.005 ) and BTT ( p < 0.0005 ) z-scores compared to the controls.
However, KS patients presented significantly higher PTH ( p < 0.0001 ) and significantly lower 25(OH)D ( p < 0.0001 ), osteocalcin ( p < 0.05 ), and bone alkaline phosphatase levels ( p < 0.005 ).
Interestingly, these metabolic bone disorders were already present in the prepubertal subjects.
Conclusions.
KS children and adolescents exhibited impaired bone mineral status and metabolism with higher PTH levels and a significant reduction of 25-OH-D and bone formation markers.
Interestingly, this impairment was already evident in prepubertal KS patients.
Follow-ups should be scheduled with KS patients to investigate and ameliorate bone mineral status and metabolism until the prepubertal ages.
American Psychological Association (APA)
Stagi, Stefano& Di Tommaso, Mariarosaria& Manoni, Cristina& Scalini, Perla& Chiarelli, Francesco& Verrotti, Alberto…[et al.]. 2016. Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105835
Modern Language Association (MLA)
Stagi, Stefano…[et al.]. Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105835
American Medical Association (AMA)
Stagi, Stefano& Di Tommaso, Mariarosaria& Manoni, Cristina& Scalini, Perla& Chiarelli, Francesco& Verrotti, Alberto…[et al.]. Bone Mineral Status in Children and Adolescents with Klinefelter Syndrome. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105835