The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
The effect of metformin in combination with insulin in adolescents with type 1 diabetes (T1DM) is controversial.
Methods and Results.
The PubMed and EMBASE online databases were searched.
Five double-blind randomized controlled trials (RCTs) that included 301 adolescents with T1DM were identified.
Metformin plus insulin was associated with reduced hemoglobin A1C levels, total daily insulin dosage, body mass index (BMI), and body weight.
However, the subgroup analysis demonstrated that HbA1c levels were not significantly changed in overweight/obese adolescents and were significantly reduced in the general patients.
On the contrary, BMI and body weight were significantly reduced in overweight/obese adolescents but not in the general patients.
Metformin was associated with higher incidence of adverse events.
Conclusions.
Among adolescents with T1DM, administering adjunctive metformin therapy in addition to insulin was associated with improved HbA1c levels, total daily insulin dosage, BMI, and body weight.
However, there may be differences in the effects of this regimen between overweight/obese and nonobese adolescents.
The risk of an adverse event may be increased with metformin treatment.
These results provide strong evidence supporting future high-quality, large-sample trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Wei& Yang, Xiao-Jie. 2016. The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Wei& Yang, Xiao-Jie. The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1105866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Wei& Yang, Xiao-Jie. The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر