The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Joint Authors
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
The effect of metformin in combination with insulin in adolescents with type 1 diabetes (T1DM) is controversial.
Methods and Results.
The PubMed and EMBASE online databases were searched.
Five double-blind randomized controlled trials (RCTs) that included 301 adolescents with T1DM were identified.
Metformin plus insulin was associated with reduced hemoglobin A1C levels, total daily insulin dosage, body mass index (BMI), and body weight.
However, the subgroup analysis demonstrated that HbA1c levels were not significantly changed in overweight/obese adolescents and were significantly reduced in the general patients.
On the contrary, BMI and body weight were significantly reduced in overweight/obese adolescents but not in the general patients.
Metformin was associated with higher incidence of adverse events.
Conclusions.
Among adolescents with T1DM, administering adjunctive metformin therapy in addition to insulin was associated with improved HbA1c levels, total daily insulin dosage, BMI, and body weight.
However, there may be differences in the effects of this regimen between overweight/obese and nonobese adolescents.
The risk of an adverse event may be increased with metformin treatment.
These results provide strong evidence supporting future high-quality, large-sample trials.
American Psychological Association (APA)
Liu, Wei& Yang, Xiao-Jie. 2016. The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105866
Modern Language Association (MLA)
Liu, Wei& Yang, Xiao-Jie. The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1105866
American Medical Association (AMA)
Liu, Wei& Yang, Xiao-Jie. The Effect of Metformin on Adolescents with Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105866